Expression of cancer testis antigens and its correlation with clinicopathological parameters in hepatocellular carcinoma

نویسندگان

  • Meng Wang
  • Xin-feng Chen
  • Zhi-qin Li
  • Zhen Zhang
  • Dong-li Yue
  • Yan-hong Liu
  • Dong Jiang
  • Yu-ling Sun
  • Yong-fu Zhao
  • Shu-huan Wu
  • Jian-sheng Li
  • Yi Zhang
چکیده

Results 87.3% of HCC tumor tissue samples expressed at least 1 CTAs. HCC adjacent non-cancerous tissues did not express CTAs. 78.9% tumor tissue samples expressed MAGE-A3 mRNA, 33.8% samples expressed MAGE-A4 mRNA, 74.6% samples expressed MAGE-C2 mRNA and 14.1% samples expressed NY-ESO-1 mRNA. The expression of CTAs showed correlation with Ki67(r=0.27, P=0.02) and tumor stages (r=0.31, P=0.01), no correlation with clinical parameters such as age, gender, ALT, HLAA2 positive, CA125, CA199, HBV or HCV infection and tumor size (P>0.05). The expression of MAGE-A3 showed correlation with the high expressions of CEA in serum (r=0.30, P=0.03), AFP in serum (r=0.26, P=0.03) and lymph node metastases (r=0.30, P=0.01).

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عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2013